What question did this study set out to answer?

The study aims to assess how different vaccination routes influence early-life germinal center dynamics and antibody production.

May 9, 2026Frontiers in ImmunologyOpen Access

Parenteral neonatal priming followed by heterologous mucosal booster favors IgM+ memory B cell induction over systemic plasma cell differentiation

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The study aims to assess how different vaccination routes influence early-life germinal center dynamics and antibody production.
Mice received homologous or heterologous immunizations followed by analysis of lymph nodes and spleens.
Evaluated germinal center B cells, T follicular helper cells, memory B cells, and antibody-secreting cells.
Assessed BAFF-R and TACI expression levels on relevant B cell populations.
Heterologous s.c./i.n. immunization favored IgM+ memory B cell induction across lymphoid tissues.
Homologous s.c./s.c. immunization resulted in enhanced plasma cell differentiation and elevated serum IgG levels.
Vaccination route directed the anatomical site of germinal center activity, influencing systemic versus mucosal antibody responses.

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Implication

Randomized trial evaluates mucosal versus systemic booster effects on immune responses in mice, indicating vaccination route shapes antibody production.

Cite This Study

Pajoohian et al. (2026) studied this question.

synapsesocial.com/papers/69fece83b9154b0b82875f2d https://doi.org/10.3389/fimmu.2026.1792155

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Implication

Randomized trial evaluates mucosal versus systemic booster effects on immune responses in mice, indicating vaccination route shapes antibody production.

Parenteral neonatal priming followed by heterologous mucosal booster favors IgM+ memory B cell induction over systemic plasma cell differentiation

Key Points

Discussion

Implication

Cite This Study

Parenteral neonatal priming followed by heterologous mucosal booster favors IgM+ memory B cell induction over systemic plasma cell differentiation

Key Points

Discussion

Implication

Cite This Study

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