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A Novel PET/CT Tracer for Human Urokinase-Type Plasminogen Activator Receptor | Synapse

May 9, 2026Journal of Medicinal Chemistry0 citations

A Novel PET/CT Tracer for Human Urokinase-Type Plasminogen Activator Receptor

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GZGangzhong ZhouChinese Academy of Medical Sciences & Peking Union Medical College XSXudong SunAcademy of Medical Sciences GCGong ChenAcademy of Medical Sciences

Key Points

This research aims to assess the utility of Ga-PDT02 as a PET radiotracer for visualizing uPAR in aggressive tumors.
Evaluated the pharmacokinetics and imaging performance of Ga-PDT02.
Demonstrated non-invasive visualization of uPAR expression.
Ga-PDT02 showed favorable pharmacokinetics in preclinical models.
Imaging performance supports its potential for detecting aggressive tumors.

Abstract

Ga-PDT02 as a promising uPAR-targeted PET radiotracer with favorable pharmacokinetics and imaging performance, supporting its potential utility for non-invasive visualization of uPAR expression in aggressive tumors.

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Cite This Study

Zhou et al. (Wed,) studied this question.

synapsesocial.com/papers/69fececcb9154b0b828761b1 https://doi.org/https://doi.org/10.1021/acs.jmedchem.6c00872