Regulation on the Electrospinnability and Mechanical Property of Bioelastomers for Small-Diameter Vascular Grafts

-PMCL) elastomers were synthesized. It was revealed that rapid crystallization promoted uniform, bead-free fibers, and ABA-type copolymers exhibited better elastic recovery than BAB types. To optimize both the electrospinnability and mechanics, the ABA3 copolymer was selected to fabricate grafts. It was demonstrated that the grafts had a tensile strength of 3.99 ± 0.15 MPa and a high compliance of 9.62 ± 0.85%/100 mmHg, perfectly matching those of native blood vessels. Additionally, the grafts showed excellent cytocompatibility, supporting cell growth over 5 days. Ultimately, these elastomers synergize excellent electrospinnability with biomimetic mechanics, offering a highly effective strategy for developing small-diameter vascular prostheses.