What question did this study set out to answer?

The study aims to explore the relationship between blood viscosity and changes in vaso-occlusive crisis frequency in sickle cell anemia patients.

May 9, 2026Blood Cells Molecules and DiseasesOpen Access

Should we longitudinally monitor blood viscosity in patients with sickle cell anemia?

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The study aims to explore the relationship between blood viscosity and changes in vaso-occlusive crisis frequency in sickle cell anemia patients.
Analyzed 63 sickle cell anemia patients over two occasions with a mean difference of 5.7 years between blood samplings.
Measured vaso-occlusive crisis rates and biological parameters, including blood viscosity and white blood cell counts.
Conducted a multivariate linear regression analysis to assess independent associations between blood viscosity and delta-VOC rate.
A positive correlation was found between delta-VOC rate and changes in blood viscosity, white blood cells, and lactate dehydrogenase.
Blood viscosity was the only parameter independently associated with changes in VOC rate (β coefficient = 0.025, 95% CI: 0.009–0.040, p < 0.01).
The regression model was statistically significant (R 2 = 0.47, p < 0.01).

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Implication

Randomized trial finds associations between blood viscosity changes and vaso-occlusive crisis frequency in sickle cell anemia patients, suggesting a need for monitoring.

Cite This Study

Connes et al. (2026) studied this question.

synapsesocial.com/papers/69fecf16b9154b0b828762cb https://doi.org/10.1016/j.bcmd.2026.103008

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Implication

Randomized trial finds associations between blood viscosity changes and vaso-occlusive crisis frequency in sickle cell anemia patients, suggesting a need for monitoring.

Should we longitudinally monitor blood viscosity in patients with sickle cell anemia?

Key Points

Discussion

Implication

Cite This Study

Should we longitudinally monitor blood viscosity in patients with sickle cell anemia?

Key Points

Discussion

Implication

Cite This Study

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