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May 6, 2026

¹H R1ρ relaxation identifies a hidden intermediate in DNA base-pairing.

Rubin Dasgupta Christian Steinmetzger Julian Ilgen Katja Petzold

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Key Points

The research aims to uncover a hidden intermediate in DNA base-pairing using relaxation dynamics.
Conducted RD studies to explore DNA dynamics.
Investigated the impacts of drug stabilization on DNA base-pairing.
Analyzed relaxation rates to identify intermediates.
Identified a previously hidden intermediate in DNA base-pairing.
Demonstrated that drug stabilization affects the dynamics of DNA interactions.

Implication

RD studies reveal a drug-stabilized intermediate in DNA base-pairing dynamics, indicating novel insights.

Abstract

RD studies, and a mechanistic discovery of a drug-stabilised intermediate in DNA base-pairing dynamics.

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Cite This Study

Dasgupta et al. (2026) studied this question.

synapsesocial.com/papers/69fecf16b9154b0b8287636d https://doi.org/10.1038/s41467-026-72559-6

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