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May 6, 2026Journal of Nuclear Medicine

Lack of LAT1 and CD98hc Expression on Tumor Cells of Diffuse Glioma: Revisiting the Molecular Basis for Amino Acid PET Imaging and Theranostics

Jan-Michael Werner Erwin Tomasich Maximilian J. Mair Johannes A. Hainfellner Georg Widhalm Marcus Hacker Norbert Galldiks Nathalie L. Albert Anna S. Berghoff Matthias Preusser

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Key Points

This research aims to clarify the molecular mechanisms behind amino acid uptake in diffuse glioma.
Investigated the expression levels of LAT1 and CD98hc on tumor cells in diffuse glioma.
Utilized amino acid tracers for PET imaging analysis.
Found a lack of LAT1 and CD98hc expression on tumor cells in diffuse glioma, which may influence tracer uptake.
Suggested further exploration for enhancing theranostic applications in glioma treatment.

Implication

Further studies uncover the role of LAT1 and CD98hc in amino acid uptake in glioma, indicating potential for improved theranostics.

Abstract

Further studies to clarify the molecular basis of amino acid tracer uptake in diffuse glioma are warranted.

Discussion

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Cite This Study

Werner et al. (2026) studied this question.

synapsesocial.com/papers/69fecf49b9154b0b828763f1 https://doi.org/10.2967/jnumed.125.271348

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1P03.26.A LACK OF LAT1/CD98 EXPRESSION ON TUMOR CELLS OF [¹⁸F]FET PET POSITIVE IDH-MUTANT GLIOMA: REVISITING THE MOLECULAR BASIS FOR AMINO ACID PET IMAGING AND THERANOSTICS2025
2Discovery of Novel LAT1-Targeted PET Tracers from <sup>18</sup> F-Labeled Aromatic Amino Acids via Photocatalyzed <sup>18</sup> F-Fluorination2025
3Abstract IA001: Advantages and challenges of amino acid PET imaging in patients with brain tumorsOriginal Research · 2026
4Diagnostic Accuracy of Amino Acid PET for Differentiating Tumor Recurrence or Progression from Treatment-Related Changes in Glioma Patients: A Systematic Review and Meta-AnalysisMeta-Analysis · 2026
5The Potential Complementary Role of Imaging with 68Ga[68Ga-RGD] PET and MRI in Recurrent Adult Glioma2024

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Association of tumor metabolic parameters on amino acid PET/CT with EGFR expression2026
EXTH-94. Can the tumor microenvironment attenuate drug efficacy? Potential vulnerabilities of LAT1 inhibitors2025
Intracranial Human BT12 Glioblastoma Xenograft is [ <sup>18</sup> F]FET PET Negative but 6-[ <sup>18</sup> F]Fluoronicotinic Acid PET Positive: Exploring a Novel Approach for Clinical Glioblastoma Imaging2026

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