What question did this study set out to answer?

The aim is to evaluate the effectiveness of phage therapy against Stenotrophomonas maltophilia using preclinical data.

May 9, 2026Future Microbiology0 citations

Meta-analysis of preclinical evidence supporting phage therapy against Stenotrophomonas maltophilia

HSHamid SadeghiQazvin University of Medical Sciences SKSaeideh Gholamzadeh KhoeiQazvin University of Medical Sciences AJAmir JavadiUniversity of Tehran

Key Points

The aim is to evaluate the effectiveness of phage therapy against Stenotrophomonas maltophilia using preclinical data.
Data from preclinical models of infection were analyzed.
Survival outcomes were measured and pooled using a fixed-effects model.
Subgroup and sensitivity analyses were conducted.
Phage therapy significantly improved survival outcomes (p<0.001).
The analysis supports phage therapy as a rapid and targeted approach.
Findings endorse the need for antimicrobial stewardship efforts.

Abstract

AIM: in preclinical models. MATERIALS AND METHODS: infections with survival outcomes. Data were pooled using a fixed-effects model, with subgroup and sensitivity analyses. PROTOCOL REGISTRATION: www.crd.york.ac.uk/prospero identifier is CRD420251059693. RESULTS: < 0.001). CONCLUSION: . It represents a rapid, targeted, and antibiotic-sparing approach, supporting future antimicrobial stewardship efforts and informing the design of clinical applications.

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