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Evaluate and compare the effectiveness of various databases and search methods in identifying randomized controlled trials for migraine treatments.

Evaluating search approaches for a network meta-analysis: a case study of Epistemonikos Database of Trials, CENTRAL, and other sources

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Evaluate and compare the effectiveness of various databases and search methods in identifying randomized controlled trials for migraine treatments.
Compared MEDLINE, Embase, CENTRAL, EDT, and reference checking for recall and precision in identifying RCTs.
Assessed the impact of search results on network meta-analysis findings regarding migraine treatments.
Evaluated the ease of systematic searching with the new Epistemonikos Database of Trials.
Recall rates were high across all approaches (98.3-100%) for identifying trials, with varying NNR and F-scores.
Different search strategies yielded similar network estimates and certainty of evidence ratings.
EDT was efficient for systematic searching and presented a promising no-cost option for trial identification.

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Case study compares search strategies for identifying RCTs in migraine treatments, indicating similar network meta-analysis outcomes.

Klerings et al. (2026) studied this question.

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