Objectives/Goals: Multiple sclerosis (MS) is an autoimmune disease located within the central nervous system. Evidence suggests nutrition may affect MS progression, but intervention research remains early. This study aims to identify barriers to dietary adherence hindering successful translation of dietary interventions into large-scale effectiveness studies. Methods/Study Population: We are currently conducting the Functional Outcomes of Diet in Multiple Sclerosis (FOOD for MS) study, a randomized controlled feeding trial testing the efficacy of two diet interventions for improving symptoms of MS. Participants who complete FOOD for MS will be invited to complete an individual interview. We will use a semi-structured interview guide based on the Health Action Process Approach to complete the interviews. Interviews will be recorded via Zoom, transcribed using Microsoft 365 transcription, and thematically analyzed using NVivo Software to derive themes related to diet adherence. Results/Anticipated Results: Study findings will describe key themes related to barriers and facilitators of long-term adherence to the FOOD for MS diets. Anticipated barriers may relate to study structure and dietary maintenance, while potential facilitators may involve behavioral supports and study incentives. Participants will also provide recommendations for enhancing the behavioral support components of the intervention to promote sustained adherence. Discussion/Significance of Impact: Results from this qualitative interview will guide refinement to the FOOD for MS protocols and support the development effectiveness and implementation trials.
Mintz et al. (Wed,) studied this question.