258 The impact of intrapartum depression on gestational weight gain and postpartum weight retention

Objectives/Goals: This study aims to understand the relationship of intrapartum depression with gestational weight gain and postpartum weight retention, given the inconsistent findings in prior research. These findings could inform intervention strategies to prevent maternal and fetal obstetric consequences as well as future maternal cardiometabolic sequelae. Methods/Study Population: We analyzed data from a randomized controlled trial at a tertiary care center. Participants had singleton pregnancies <15 weeks gestational age and BMI >=25; those with diabetes, severe hypertension, history of preterm birth, psychiatric illness, or substance use disorders were excluded. Baseline demographic and obstetric characteristics were obtained. Depression was measured using a modified Edenborough Postnatal Depression Scale (EDPS). Maternal weights were a combination of measured clinical weights and self-reported weights. These were used in conjunction with CDC guidelines to determine adequate, excessive, or inadequate gestational weight gain at 37 weeks as well as to assess weight retention at 6 months postpartum. Regression analyses will be conducted in Stata18. Results/Anticipated Results: There were 375 participants enrolled in the study. Of these participants, 54.7% were White, 29.9% Black, 5.9% Asian, and 9.6% multi-racial/other; 9.1% were of Hispanic ethnicity. Mean age was 32.8 (SD: 5.0), and mean baseline weight was 198.8 lbs (SD: 39.9). Early pregnancy (<15 weeks gestation) BMI distribution was 35.5% 25-29.9 kg/m 2 , 48.0% 30-39.9 kg/m 2 , and 16.5% >= 40. Mean baseline EDPS score was 6.1. Planned analyses will evaluate the associations between baseline EDPS scores and (1) gestational weight gain at 37 weeks and (2) postpartum weight retention at 6 months. We hypothesize that higher baseline EPDS values will be associated with increased gestational weight gain and increased postpartum weight retention. Discussion/Significance of Impact: Excessive weight gain in pregnancy increases risk for complications such as preeclampsia, gestational diabetes mellitus, and need for a Caesarian section. Postpartum weight retention increases risk for future cardiometabolic disease. Understanding risk factors for excess weight gain/retention will inform targeted screening and interventions.