45 Say it plain and proud: Supporting evidence-based recommendations of the HPV vaccine in a matched-pair pilot trial of implementation strategies

Objectives/Goals: To evaluate midstream outcomes of a pilot trial testing co-created implementation strategies that support rural Arkansas providers in using the announcement approach to deliver stronger, evidence-based HPV vaccine recommendations. Methods/Study Population: We conducted a matched-pair pilot trial in four primary care clinics serving rural populations in Arkansas. We co-created a bundle of implementation strategies with local experts using an evidence-based quality improvement process to support announcement approach HPV vaccine recommendations. We used a mixed methods approach to collect data on feasibility and acceptability of the bundled strategies and innovation, self-reported fidelity, and uptake of the HPV vaccine during the study period. This pilot will be used to support a subsequent full-scale hybrid-type effectiveness-implementation trial of the bundled strategies and evidence-based recommendations. Results/Anticipated Results: We anticipate that intervention clinics will demonstrate improvement in the primary study outcomes related to implementation of the locally-tailored strategies and innovation, e.g., feasibility and acceptability. We also anticipate a higher proportion of providers in intervention clinics will use the announcement approach for recommendations of the HPV vaccine to eligible patients. We also anticipate increases in HPV vaccine initiation among eligible patients especially in intervention clinics. This research was supported by the UAMS Translational Research Institute and the National Center for Advancing Translational Sciences (UM1TR004909/1K12TR004924). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Discussion/Significance of Impact: Our findings highlight how co-created implementation strategies can strengthen provider communication and boost HPV vaccine uptake in rural clinics, advancing equitable cancer prevention and informing scalable, evidence-based practices in underserved regions.