Objectives/Goals: Apply the NCATS translational science principles as a framework to describe CTSA UM1 hub activities in terms of effective translational science approaches. Identify and characterize the distribution of principles across UM1-funded initiatives to support strategic management and reporting. Methods/Study Population: Hub-affiliated faculty and staff convened at an annual, in-person retreat for the Northwestern University Clinical and Translational Sciences (NUCATS) Institute. Module teams, including at least one co-lead from Workforce Development for Clinical Research Staff Professionals (C1), Community and Partner Engaged Research (C2), Resources and Services (D1), and Health Informatics (D3), completed a concept mapping exercise to identify which, if any, of the 7 translational science principles were exemplified by their initiatives. Teams worked collaboratively to map principles to each initiative. Data were aggregated at the module and hub levels. Results/Anticipated Results: Each module reported 5–10 active, UM1-funded initiatives. Every initiative was mapped to>2 translational science principles, with 2 initiatives mapped to all 7 principles. On average, 4.6 principles were identified per initiative. “Focus on Unmet Needs” was the most highly reported across all initiatives. “Boundary-Crossing Partnerships,” mapped to all Community and Partner Engaged Research (C2) projects, and “Creativity and Innovation” mapped to all resources and services (D1). 90% of Informatics (D3) initiatives were mapped to “Generalizable Solutions.” Across the hub, “Bold and Rigorous Approaches” was the least likely to be identified. Discussion/Significance of Impact: The translational science principles can be used to frame module-specific and hub-wide strengths and gaps. Concept mapping can be incorporated into project planning and reporting to increase shared understanding and alignment with the principles that support the translational science enterprise.
Bucek et al. (2026) studied this question.