Structural Retinal and Choroidal Changes in Toxoplasmic Retinochoroiditis Assessed by Swept-Source Optical Coherence Tomography

PURPOSE: To demonstrate retinal and choroidal structural changes across distinct disease activity phases in toxoplasma retinochoroiditis (TRC) using swept-source optical coherence tomography (SS-OCT) and establishing stage-specific imaging biomarkers for therapeutic decisions and monitoring. METHODS: = 27) using standardized clinical/serological criteria. SS-OCT measured central foveal thickness (CFT), subfoveal choroidal thickness (SFCT), retinal layers, and vitreous changes. Interobserver reproducibility assessed via intraclass correlation coefficients (ICC). Continuous parameters compared using Kruskal-Wallis H test with Dunn's post-hoc correction. Multivariate logistic regression controlled for age, sex, lesion location, and bilaterality. Serous retinal detachment 17.9% (mostly active), no recurrence. ICC > 0.85 confirmed measurement reproducibility. CONCLUSIONS: SS-OCT reveals distinct structural signatures across TRC phases: active disease shows retinal edema and vitreoretinal disruption; reactive phases exhibit transitional remodeling; inactive disease manifests chronic atrophy. SS-OCT validates quantifiable disease staging, treatment monitoring, and prognostication. Future multimodal imaging studies needed.