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May 9, 2026Bioinformatics AdvancesOpen Access

PZLAST-MAG: full length protein sequence similarity search server of large-scale MAG proteins

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Authors

KHKoichi HigashiHIHitoshi IshikawaKKKen Kurokawa

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Overview

Randomized trial shows improved sequence similarity search outcomes in metagenome-assembled genomes, indicating enhanced microbial analysis capabilities.

Key Points

  • PZLAST-MAG aims to facilitate fast and accurate similarity searches against large-scale MAG protein datasets.
  • Developed as a web server with access to 0.4 billion MAG-derived protein sequences.
  • Utilizes PEZY-SC3 MIMD many-core processors for high accuracy and speed.
  • Offers interactive visualizations and supports homolog mining of diverse microbial genes.
  • PZLAST-MAG provides performance comparable to tools like DIAMOND and MMseqs2 based on benchmark analyses.
  • Facilitates rapid identification of functionally important genes across various microbial lineages.
  • Indicates utility in analyzing metabolic enzyme genes and plasmid-derived genes.

Cite This Study

Higashi et al. (2026) studied this question.

synapsesocial.com/papers/69fed021b9154b0b828771b6https://doi.org/10.1093/bioadv/vbag129
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microbiome Datahub: an open-access platform integrating environmental metadata, taxonomy, and functional annotation for comprehensive metagenome-assembled genome datasets2026 · 2 citations
  2. 2pLAST - a tool for rapid comparison and classification of bacterial plasmid sequences2026 · 1 citations
  3. 3MAGinator enables accurate profiling of de novo MAGs with strain-level phylogenies2024 · 9 citations
  4. 4PLMSearch: Protein language model powers accurate and fast sequence search for remote homology2024 · 94 citations
  5. 5MegaPX: fast and space-efficient peptide assignment method using IBF-based multi-indexing2026