Key result
Statin discontinuation is linked to higher cardiovascular events, hospitalizations, and all-cause mortality across studies.
Why the study?
What are the epidemiology, clinical determinants, and consequences of statin discontinuation?
Population
Patients prescribed statin therapy (including primary and secondary prevention populations)
Comparison
Statin discontinuation or suboptimal adherence vs Statin continuation or optimal adherence
Design
Review
Authors
Loading...
Statin discontinuation is highly prevalent, particularly in primary prevention, and is consistently associated with increased cardiovascular events and mortality, emphasizing the critical need to address barriers to adherence.
What are the epidemiology, clinical determinants, and consequences of statin discontinuation?
Statin discontinuation is highly prevalent, particularly in primary prevention, and is consistently associated with increased cardiovascular events and mortality, emphasizing the critical need to address barriers to adherence.
Orfanos et al. (2026) conducted a review in Cardiovascular disease. Statin discontinuation was evaluated on Cardiovascular events, hospitalizations, and all-cause mortality. Statin discontinuation is common, with first-year rates ranging from 0.8% to 70.5%, and is consistently associated with increased cardiovascular events, hospitalizations, and all-cause mortality.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: