Objectives/Goals: The “Reducing Disability in Alzheimer’s Disease” (RDAD) intervention promotes physical function for people with dementia and reduces caregiver burden but has never been tested in adults with Down syndrome despite their 90% lifetime risk of Alzheimer’s disease. Our objective is to modify RDAD for the needs of this population using the ADAPT framework. Methods/Study Population: We worked collaboratively with families, self-advocates, and professionals to conduct a 2-phase adaptation process of the RDAD intervention materials, content, and mode of delivery. In Phase 1, we convened focus groups comprised of adults with Down syndrome, caregivers, community-based disability service professionals, and researchers to review and advise changes to the RDAD intervention and analyzed their feedback qualitatively using content and thematic analysis. In Phase 2, we conducted a 4-week usability pilot test of RDAD with 5 older adults with Down syndrome and their caregivers to gather additional feedback on intervention feasibility, usability, and acceptability using weekly surveys and a final interview. Results/Anticipated Results: In Phase 1, twelve stakeholders met for four 90-minute focus group sessions. Based on their feedback, we modified the mode of delivery (remote delivery) and changed from one-on-one to group classes to support social connectedness. In the revised materials, we addressed the broad resource needs around dementia diagnosis, healthcare, and caregiving. We updated intervention materials to make them more usable and attractive and integrated music into the live, remote exercise classes, which include a person with Down syndrome as an instructional assistant. In Phase 2, we tested the revised intervention for 4 weeks and collected preferences for the exercise classes, content for the caregiver training, and modes of delivery. We have integrated these findings into the revised intervention and renamed it CareFit-DSAD. Discussion/Significance of Impact: We adapted an evidence-based intervention to the needs of families with Down syndrome using input and evaluation by key stakeholders. The adapted intervention is now undergoing a 12-week pilot and feasibility test ( n = 20 dyads) to further assess feasibility, acceptability, and preliminary changes in physical function and caregiver burden.
Bodde et al. (Wed,) studied this question.