460 Natural interventions in breast cancer: Evidence from a comprehensive survey

Objectives/Goals: To observe mechanisms of natural supplements and their links and similar pathways to chemotherapy and hormone therapy in order to use natural therapies as a way to ease treatment side effects in breast cancer patients. Methods/Study Population: A systematic search was conducted using databases such as PubMed and Google Scholar, using search terms “breast cancer,” “treatment,” “pathways,” “targets,” and “cell lines” in combination with “natural therapies” as well as “hormone therapies” and “chemotherapies” to understand drug and supplement mechanisms. ClinicalTrials.gov was used to investigate studies using natural therapies used to treat side effects of cancer treatments. Promising results were discovered on the effectiveness of natural therapies and their correlation with treatment for breast cancer. Results/Anticipated Results: Preclinical evidence supports 23 natural remedies being used to ease side effects brought on by chemotherapy. These natural supplements are shown to affect at least one of the seven breast cancer cell lines observed. Fifty-two total clinical trials were used to verify the preclinical models of the 23 natural remedies, and the clinical trials would be patient symptom assessment-based, or determining tumor growth or shrinkage. Many of these clinical trials, however, did not supply results. This shows that there is a gap in getting participants for oncology-related clinical studies. With the trials that supplied results, 16 natural remedies have clinical data showing their ability to be used to ease common chemotherapy side effects, or even further leading to cancer death in related cell lines. Discussion/Significance of Impact: There are not many specific findings about young women and post-menopausal women being affected by breast cancer (despite being more sensitive groups). Looking into differences in biology, reactions to treatment and effectiveness of treatment, and clinical trials with supplements between these groups could address issues affecting them.