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May 9, 2026Phytochemical Analysis

Investigation of the Chemical Constituents and Hepatic‐Exposed Components of the Bupleuri Radix–Rhei Radix et Rhizoma Herbal Pair Based on UPLC‐Q‐Orbitrap‐MS Analysis

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Authors

XDXinyu DaiJMJie MaQLQian Lü

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Overview

Randomized trial investigates liver-exposed components of Bupleuri Radix-Rhei Radix, highlighting its chemical profile.

Key Points

  • The aim is to characterize the chemical constituents of the Bupleuri Radix-Rhei Radix aqueous extract and identify the liver-exposed components.
  • UPLC-Q-Orbitrap-MS used for analysis of BR-RR aqueous extract and liver-exposed components in mice after oral administration.
  • Retention times, accurate molecular weights, and multistage MS fragmentation data were utilized for compound identification.
  • 109 compounds were identified in the BR-RR extract, including anthraquinones and flavonoids.
  • 25 prototype components and 21 metabolites were characterized in mouse liver samples after oral administration.
  • Anthraquinones were the predominant class found in the liver.

Cite This Study

Dai et al. (2026) studied this question.

synapsesocial.com/papers/69fed0abb9154b0b82877b67https://doi.org/10.1002/pca.70076
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