This research demonstrates site-selective functionalization of C(sp3)–H bonds, suggesting a new synthetic approach.
A site-selective functionalization of C(sp3)–H bonds is described. Electrophilic alkenes and alkynes are used to perform the site-selective functionalization of tertiary C(sp3)–H bonds enabled by merging a tetrabutylammonium decatungstate (TBADT) as a hydrogen atom abstractor (HAA) and a thiol as a hydrogen atom donator (HAD) under light irradiation. Excess use of substrates could be avoided; greater than 20:1 site selectivity and up to 84% yield could be obtained with the help of 2,4,6-tri-tert-butylbenzenethiol.
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Xu et al. (2026) studied this question.
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