124 Exploring the biological embedding of adversity and cardiometabolic disease risk

Objectives/Goals: Conception to early childhood is reported to be one of the most critical developmental periods in human development. This study examines the role of adversity experienced by both mom and child during the pre-and post-natal periods on children’s cardiometabolic disease risk (CMDR) outcomes. Methods/Study Population: Data include responses from 852 biological mother-child dyads from the Family Life Project. Adversity during pregnancy was measured using the Life Experiences Survey. The number of life experiences that mothers reported as “bad” was included in the analyses. Children’s experiences with adversity were assessed using cumulative risk, a composite measure of adversity captured at four time points: 6, 15, 24, and 35 months. These variables were used to predict children’s obesity and mean arterial pressure, markers of cardiometabolic disease risk. Children’s obesity status was measured using standardized body mass index (BMIZ) values, assessed in children when they were 24, 35, 48, 58, 90, and 154 months. Mean arterial pressure was captured at 154 months. Results/Anticipated Results: Less than half of mothers (42.4%) and children (44.6%) identified as Black. Roughly half of the children (49.1%) were female. Most (78.2%) mothers were categorized as being of low economic status. Preliminary analyses revealed that number of negative life experiences reported by mothers were not significantly correlated with MAP. Children’s cumulative risk (CR) at 6 (r=0.11, p<0.01), 15 (r=0.11, p<0.01), 24 (r=0.11, p<0.01), and 35 (r=0.10, p<0.01) months were significantly correlated mean arterial pressure (MAP) at age 14. Associations between CR and MAP remained significant among girls at all time points and among boys only at months 6,15, and 24 months. There were no significant correlations between adversity experienced in utero on children’s BMIZ values at any timepoint. Discussion/Significance of Impact: The American Heart Association states that MAP is often used as an indicator of CMDR. Preliminary results from this study suggest a potential pathway from adversity experienced in infancy and adolescent MAP. Future studies should further explore these associations to better understand the pathways from early life adversity to high CMDR.