110 A Positive Lens on Perinatal Health: Dimensions of Well-Being as Protective Factors Against Preterm Birth

Objectives/Goals: The objectives of this project were to (1) develop a multidimensional well-being index, reflecting personal capacities and environmental conditions, and (2) evaluate its association with preterm birth. The goal of this investigation was to illustrate the value of multidimensional well-being for understanding health outcomes. Methods/Study Population: The LIFE study was a retrospective cohort of postpartum US-born Black women (ages 18+) recruited 2009–2011 from a suburban Detroit hospital. Eligible participants self-identified as African American, had singleton births, and spoke English; exclusions included incarceration, cognitive impairment, or serious mental health conditions. Trained interviewers collected survey and medical data during postpartum stays. Of 1,410 recruits (71% response), 1,177 had complete data. Key variables were binarized; logistic regression models assessed associations with preterm birth. Results/Anticipated Results: Few of the 21 binarized variables showed individual statistical significance. Significant predictors included having someone to offer advice about a crisis or to listen when needing to talk about oneself or one’s problems, and self-rated physical and mental health satisfaction. Of the dimension scales, only the physical health scale (physical health rating, mental health rating, and mental health satisfaction) was significant. The overall well-being index was borderline significant for lower odds of preterm birth (OR=0.934, 95% CI: 0.887–1.002, p=0.0593), reaching significance when adjusted for maternal age (OR=0.938 95% CI: 0.883-0.998, p=0.0414). Discussion/Significance of Impact: This study’s findings underscore that well-being is best understood as a holistic interconnected construct. By centering context, this approach advances health equity, encourages systemic accountability and change, and inspires innovative public health research.