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January 1, 2026Open Access

Synaptic transmission: Munc13 assembles onto PI(4,5)P 2 -rich domains into trimers that cooperate to capture vesicles

Feng Li Abhijith Radhakrishnan Sudhan Gautam Gabriel Diaz Kalyan Sundaram Jeff Coleman Hong Zheng Kirill Grushin Matthieu Chavent Rothman, James, E Frederic Pincet

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Key Points

The aim is to investigate how Munc13 assembles onto PI(4,5)P2-rich domains and its role in synaptic vesicle capture.
Analyzed Munc13 interactions with PI(4,5)P2-rich domains in vitro.
Utilized imaging techniques to visualize trimer formation.
Examined vesicle dynamics during synaptic transmission using electrophysiological methods.
Munc13 forms trimers that significantly enhance vesicle capture efficiency.
Trimeric assembly positively correlates with increased synaptic transmission efficacy.

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Implication

Demonstrates how Munc13 organizes into trimers to facilitate vesicle capture during synaptic transmission.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69fed123b9154b0b82878561 https://doi.org/10.1073/pnas.25233471231of12

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