Pediatric blastic plasmacytoid dendritic cell neoplasms are molecularly defined by recurrent MYB rearrangements: clinical and molecular insights

Mahsa Khanlari; M. Nunez; Jamie L. Maciaszek; Mohammad K. Eldomery; Wei Wang; Zhongshan Cheng; Jason Myers; Karissa Dieseldorff Jones; Gabriela Gheorghe; Laura Van Key; Yen‐Chun Liu; Rafael Barceiro; Armando Peña; Sharon Castellino; Roy Rosado; Marcela Barros E Sousa; Jacob R. Bledsoe; Naveen Pemmaraju; Jeffery M. Klco; Raul C. Ribeiro

doi:10.3324/haematol.2026.300903

Key Points

The aim is to understand the molecular characteristics of pediatric blastic plasmacytoid dendritic cell neoplasms, particularly focusing on MYB rearrangements.
Analyzed clinical data of pediatric patients with blastic plasmacytoid dendritic cell neoplasms
Conducted molecular studies to identify MYB rearrangements
Identified recurrent MYB rearrangements in a significant subset of cases
Provided clinical insights that could inform future targeted therapies

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Implication

Clinical insights reveal recurrent MYB rearrangements defining pediatric blastic plasmacytoid dendritic cell neoplasms, suggesting targeted treatment avenues.

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Cite This Study

Khanlari et al. (2026) studied this question.

synapsesocial.com/papers/69fed140b9154b0b8287871b https://doi.org/10.3324/haematol.2026.300903

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Pediatric blastic plasmacytoid dendritic cell neoplasms are molecularly defined by recurrent MYB rearrangements: clinical and molecular insights

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Pediatric blastic plasmacytoid dendritic cell neoplasms are molecularly defined by recurrent MYB rearrangements: clinical and molecular insights

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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