Targeted inactivation of gamma-synuclein decreases anxiety and increases exploratory behaviour in mice, indicating its role in emotional regulation.
Gamma(γ)-synuclein is a member of synuclein family of cytoplasmic and predominantly neuronal proteins found only in vertebrates. γ-Synuclein is abundant in axons and presynaptic terminals of neurons localized in brain regions involved in emotions, learning and memory. However, the role of γ-synuclein in these brain functions was not previously assessed. We have demonstrated for the first time that the loss of γ-synuclein results in a significant increase in the level of orientation response in novel environment and decrease in the level of state anxiety.
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Kokhan et al. (2010) studied this question.
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