Isolation of a highly virulent colibactin-positive tumor-promoting strain of Escherichia coli from the gut microbiota of an adult

Allison M. Weis; O’Connor J. Matthews; Rickesha Bell; Nicole Lynn Pershing; Annika Dankwardt; Brittany A. Fleming; Biljana Gigic; Martin Schneider; Sheetal Hardikar; Adetunji T. Toriola; David Shibata; C Li; Doratha A. Byrd; W. Zac Stephens; Cornelia M. Ulrich; Matthew A. Mulvey; June L. Round

doi:10.1128/msphere.00219-26

May 7, 2026mSphereOpen Access

Isolation of a highly virulent colibactin-positive tumor-promoting strain of Escherichia coli from the gut microbiota of an adult

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Key Points

The study aims to identify a virulent colibactin-positive E. coli strain linked to tumor development.
Isolated a strain of E. coli from the gut microbiota of an adult.
Used murine models to assess tumorigenesis and impacts on kidney and inflammatory conditions.
Evaluated the strain's effects on colitis and sepsis.
The identified E. coli strain caused tumor development in mice, significantly contributing to tumorigenesis.
This strain worsened both colitis and sepsis in murine models, indicating its high virulence.
The strain led to kidney dissemination and increased mortality in mice.

Implication

Isolation identifies a virulent E. coli strain promoting tumor growth in mice, suggesting its significance in CRC research.

Abstract

coli strain that led to tumorigenesis, disseminated from the gut to the mouse kidneys, caused death, and worsened both colitis and sepsis in murine models. Identification of this strain enhances our collective knowledge and adds an important tool for future studies on the role of microbes and CRC tumorigenesis.

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Cite This Study

Weis et al. (2026) studied this question.

synapsesocial.com/papers/69fed153b9154b0b828789ca https://doi.org/10.1128/msphere.00219-26

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Isolation of a highly virulent colibactin-positive tumor-promoting strain of Escherichia coli from the gut microbiota of an adult

Key Points

Implication

Abstract

Discussion

Cite This Study

Isolation of a highly virulent colibactin-positive tumor-promoting strain of Escherichia coli from the gut microbiota of an adult

Key Points

Implication

Abstract

Discussion

Cite This Study

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