Nanoconfinement catalysis-enhanced electrochemiluminescence aptasensor for the sensitive detection of matrix metalloproteinase-9

Key Points

• The aim is to develop a sensitive electrochemiluminescence (ECL) aptasensor for detecting matrix metalloproteinase-9.
• Fabrication of an electrochemiluminescence aptasensor combining recognition interface with a nanochannel-confined Co3O4 nanozyme.
• Utilization of luminol to enhance the electrochemiluminescence signal.
• Focused on the sensitive detection of matrix metalloproteinase-9.
• The aptasensor exhibited a significant increase in ECL signal intensity compared to conventional methods.
• Demonstrated high sensitivity and specificity for matrix metalloproteinase-9 detection.