18F-FDG PET/CT imaging in a 54-year-old female with primary pulmonary epithelioid angiosarcoma revealed multiple hypermetabolic consolidations with ground-glass opacities.
Case Report (n=1)
No
18F-FDG PET/CT combined with pathological biopsy and immunohistochemistry is critical for the definitive diagnosis of the rare primary pulmonary epithelioid angiosarcoma.
This article reports a case of primary pulmonary epithelioid angiosarcoma (PEA) in a 54-year-old female. The patient presented with cough, hemoptysis, and melena, accompanied by anemia and multiple laboratory abnormalities. Imaging revealed diffuse bilateral lung lesions, and positron emission tomography/computed tomography (PET/CT) showed multiple hypermetabolic consolidations with ground-glass opacities. Pathological biopsy confirmed a poorly differentiated epithelioid malignant tumor, with immunohistochemistry positive for CD31, ERG, and FLI-1, and a PD-L1 expression rate of 50%. PEA is extremely rare and lacks specific clinical manifestations, often leading to misdiagnosis as infection or other malignancies. In this case, the diagnosis was confirmed by immunohistochemistry, and immunotherapy was recommended based on the high PD-L1 expression. The article further discusses the imaging characteristics, differential diagnosis, and therapeutic challenges of PEA, emphasizing the critical role of pathology in definitive diagnosis.
Meng et al. (Mon,) conducted a case report in Primary pulmonary epithelioid angiosarcoma (n=1). 18F-FDG PET/CT was evaluated. 18F-FDG PET/CT imaging in a 54-year-old female with primary pulmonary epithelioid angiosarcoma revealed multiple hypermetabolic consolidations with ground-glass opacities.