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May 9, 2026GeroScienceOpen Access

A conserved regulatory architecture stabilizes cellular senescence across distinct triggers in human fibroblasts

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Authors

MSMohd ShahzaibDADomenico AprileTSTiziana Squillaro

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Overview

Randomized trial investigates transcriptional similarities in senescence triggers in human fibroblasts, suggesting new therapeutic targets.

Key Points

  • This research aims to explore whether different triggers of cellular senescence in human fibroblasts exhibit a common transcriptional organization.
  • Integrated seven public human fibroblast RNA-seq datasets across triggers.
  • Conducted Gene Ontology and Reactome pathway enrichment analyses.
  • Applied protein-protein interaction network embedding to compare transcriptional responses.
  • Identified 263 commonly repressed and 112 commonly induced Gene Ontology terms.
  • Found 145 shared Reactome pathways, highlighting conserved signaling mechanisms.
  • Discovered ELAVL1 as a key regulator of senescence-associated secretory phenotype output.

Cite This Study

Shahzaib et al. (2026) studied this question.

synapsesocial.com/papers/69fed1f0b9154b0b82879097https://doi.org/10.1007/s11357-026-02297-6
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