Key result
Assisted reproductive technologies linked to a 7.4% fetal CHD prevalence with no difference between IVF and ICSI.
Why the study?
This study was conducted to determine fetal echocardiography findings and the prevalence of congenital heart disease in infants conceived via assisted reproductive technology.
What is the prevalence and spectrum of congenital heart disease detected by fetal echocardiography in pregnancies conceived via ART?
Cross-Sectional (n=230)
No
What is the prevalence and spectrum of congenital heart disease detected by fetal echocardiography in pregnancies conceived via ART?
Absolute Event Rate: 10.1% vs 4.9%
p-value: p=0.308
Fetal echocardiography reveals a 7.4% prevalence of congenital heart disease in pregnancies conceived via ART, highlighting the importance of prenatal screening in this population.
Background & Objective: Fetal echocardiography is a well-established and sensitive tool for the prenatal diagnosis of congenital heart defects. This study was conducted to determine the findings of fetal echocardiography in infants who were conceived by mothers with Assisted Reproductive Technology (ART).Materials & Methods: This descriptive cross-sectional study was conducted on all women who were pregnant with assisted reproductive technology and were subjected to echocardiography. The findings of echocardiography and the prevalence of Congenital Heart Disease (CHD) were investigated in these mothers. Data were analyzed using SPSS software (version 26) and t-test and chi-square test. P<0.05 was considered significant.Results: CHD was found in 17 cases (7.4%) and 213 cases (92.6%) did not have CHD. No significant relationship was found between mothers' age, gestational age, multiple births, type of assisted reproduction method, and heart abnormalities (P<0.05).Conclusion: Our data showed an increased prevalence of CHDs after ART with a heterogeneous spectrum of abnormalities, mainly major defects, the most common of which was tetralogy of Fallot and HLHS.
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Yousefi et al. (2026) conducted a cross-sectional in Pregnancies conceived via Assisted Reproductive Technologies (ART) (n=230). In Vitro Fertilization (IVF) vs. Intracytoplasmic Sperm Injection (ICSI) was evaluated on Prevalence of Congenital Heart Disease (CHD) (p=0.308). Assisted reproductive technologies were associated with a 7.4% overall prevalence of fetal congenital heart disease, with no significant difference in CHD frequency between IVF and ICSI methods.
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