Rare, protein-truncating variants in ATM, CHEK2 and PALB2, but not XRCC2, are associated with increased breast cancer risks

BACKGROUND: , we sequenced their coding regions in 13 087 BC cases and 5488 controls from East Anglia, UK. METHODS: algorithms. RESULTS: may contribute to BC risk, but larger studies are necessary to quantify the magnitude of this effect. CONCLUSIONS: variants can be excluded.