Does the triglyceride glycemic index associate with cardiovascular and all-cause mortality in patients with hypertension?
The triglyceride glycemic index, a marker of insulin resistance, is non-linearly associated with all-cause mortality in elderly hypertensive patients and is associated with increased cardiovascular mortality when elevated above 9.52.
BACKGROUND: To investigate the association between insulin resistance (IR), quantified by triglyceride glycemic index (TyG index), cardiovascular mortality (CVM), and all-cause mortality (ACM) in hypertension patients. METHODS: We included 8,554 patients with hypertension aged ≥18 years old from the 1999-2014 National Health and Nutrition Examination Surveys (NHANES). The status of CVM and ACM of participants were followed through December 31, 2015. Cox proportional hazards models and Kaplan-Meier survival curves were used to evaluate the relationship between TyG index, CVM, and ACM. RESULTS: < 0.05). CONCLUSIONS: We demonstrated that the association between ACM and TyG index in elderly patients with hypertension aged ≥60 years was non-linear. However, TyG index was only more than 9.52, hence, the risk for CVM would increase among the whole hypertension group.
Zhou et al. (Thu,) studied this question.