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January 6, 2014Current Gene TherapyOpen Access

Adenovirus Vectors for Gene Therapy, Vaccination and Cancer Gene Therapy

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Authors

WWWilliam S.M. WoldSaint Louis UniversityKTKároly TóthSaint Louis University

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Implication

Clinical review reveals the safety and therapeutic activity of engineered adenoviruses in clinical trials, highlighting their utility in vaccination and oncology.

Key Points

  • To review the mechanisms, genetic engineering strategies, and clinical utility of replication-defective and replication-competent adenovirus vectors in gene therapy, vaccines, and oncology.
  • Assessed replication-defective adenovirus platforms modified by deleting essential viral genes and inserting therapeutic or antigen-expressing gene cassettes.
  • Evaluated replication-competent oncolytic vectors engineered to selectively replicate within and destroy malignant cells via lytic replication.
  • Replication-defective adenoviruses reliably express foreign antigens and therapeutic transgenes for vaccination and corrective gene therapy.
  • Clinical trials confirm that both replication-defective and replication-competent oncolytic adenovirus vectors demonstrate favorable safety profiles and meaningful therapeutic activity.

Cite This Study

Wold et al. (2014) studied this question.

synapsesocial.com/papers/69ff44b5413f0c047f2d5fbfhttps://doi.org/10.2174/1566523213666131125095046
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