July 1, 1984Clinical Pharmacology & Therapeutics

Effects of propranolol and of verapamil on heart rate and blood pressure in hyperthyroidism

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Why the study?

Does verapamil improve heart rate and blood pressure compared to propranolol in patients with hyperthyroidism?

Population

8 patients with hyperthyroidism

Comparison

Verapamil (0.1, 0.2, and 0.4 mg/kg intravenously) vs Propranolol in a crossover fashion

Design

RCT, double-blind

Authors

JCJ P ClozelRoche (Switzerland)NDNicolas DanchinInterventional Cardiology PGPierre GentonCentre Hospitalier du Pays d'Aix

Discussion

Member takes

Implication

Propranolol remains first-line for rate control in hyperthyroidism; confirms its chronotropic superiority over verapamil while highlighting complementary BP effects.

Structured PICO

Does verapamil improve heart rate and blood pressure compared to propranolol in patients with hyperthyroidism?

Population

8 patients with hyperthyroidism

Intervention

Verapamil (0.1, 0.2, and 0.4 mg/kg intravenously)

Comparator

Propranolol (0.05, 0.1, and 0.2 mg/kg intravenously) in a crossover fashion

Outcome

Heart rate (RR interval), PR and QT intervals, and blood pressuresurrogate

Verapamil is not an effective alternative to propranolol for controlling heart rate in patients with hyperthyroidism.

Cite This Study

Clozel et al. (1984) studied this question.

synapsesocial.com/papers/69ff4b006018b8d0892d74fa https://doi.org/10.1038/clpt.1984.140

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Implication

Propranolol remains first-line for rate control in hyperthyroidism; confirms its chronotropic superiority over verapamil while highlighting complementary BP effects.