December 1, 2021Therapeutics and Clinical Risk Management60 citationsOpen Access

Mortality and Readmission Rates After Heart Failure: A Systematic Review and Meta-Analysis

TLTian LanUniversity of Electronic Science and Technology of China YLYanhui LiaoSir Run Run Shaw Hospital JZJian ZhangGeneral Cardiology

Structured PICO

Population

27 studies pooling 515,238 participants with heart failure, average age 76.3 years, 51% male.

Outcome

30-day and 1-year readmission rates, mortality, and risk factors for readmission and mortalityhard clinical

Heart failure hospitalization is followed by high 30-day and 1-year readmission and mortality rates.

Abstract

OBJECTIVE: The current work aimed to examine the rates of and risk factors for mortality and readmission after heart failure (HF). SETTING: A systematic search was carried out in PubMed, the Cochrane Library, and EMBASE to identify eligible reports. The random-effects model was utilized to evaluate the pooled results. PARTICIPANTS: A total of 27 studies with 515,238 participants were finally meta-analysed. The HF patients had an average age of 76.3 years, with 51% of the sample being male, in the pooled analysis. PRIMARY AND SECONDARY OUTCOME MEASURES: The outcome measures were 30-day and 1-year readmission rates, mortality, and risk factors for readmission and mortality. RESULTS: The effect sizes for readmission and mortality were estimated as the mean and 95% confidence interval (CI). The estimated 30-day and 1-year all-cause readmission rates were 0.19 (95% CI 0.14-0.23) and 0.53 (95% CI 0.46-0.59), respectively, while the all-cause mortality rates were 0.14 (95% CI 0.10-0.18) and 0.29 (95% CI 0.25-0.33), respectively. Comorbidities were highly prevalent in individuals with HF. CONCLUSION: Heart failure hospitalization is followed by high readmission and mortality rates.

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