March 3, 2022BiomedicinesOpen Access

Reactive Oxygen Species Induced Pathways in Heart Failure Pathogenesis and Potential Therapeutic Strategies

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Why the study?

Current heart failure treatment strategies mostly target neuroendocrine inhibition, while recent data on reactive oxygen species-induced metabolic pathways may provide additional therapeutic strategies and targets for HFrEF and HFpEF.

Design

Review article

Authors

AMAušra MongirdienėLithuanian University of Health Sciences LSL SkrodenisLithuanian University of Health Sciences LVLeila VaroneckaitėLithuanian University of Health Sciences

Discussion

Member takes

Implication

ROS pathways merit targeted HF trials; leaves open clinical efficacy in HFrEF/HFpEF.

Structured PICO

Population

Patients with heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), as well as preclinical models

Intervention

Treatments targeting reactive oxygen species (ROS)-induced metabolic pathways

This review highlights the role of reactive oxygen species in the pathogenesis of both HFrEF and HFpEF and discusses potential therapeutic strategies targeting these metabolic pathways.

Cite This Study

Mongirdienė et al. (2022) studied this question.

synapsesocial.com/papers/69ff76c66018b8d0892d82cf https://doi.org/10.3390/biomedicines10030602

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Reactive Oxygen Species Induced Pathways in Heart Failure Pathogenesis and Potential Therapeutic Strategies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reactive Oxygen Species Induced Pathways in Heart Failure Pathogenesis and Potential Therapeutic Strategies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider