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January 17, 2025Science ImmunologyOpen Access

Architects of immunity: How dendritic cells shape CD8 ⁺ T cell fate in cancer

Vidit Bhandarkar Teresa Dinter Stefani Spranger

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T cell fates.

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Bhandarkar et al. (2025) studied this question.

synapsesocial.com/papers/69ff77cb6018b8d0892d8331 https://doi.org/10.1126/sciimmunol.adf4726

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector FunctionOriginal Research · 1998 · 1,979 citations
2Exhaustion-associated regulatory regions in CD8 <sup>+</sup> tumor-infiltrating T cellsOriginal Research · 2017 · 310 citations
3The epigenetic landscape of T cell exhaustionOriginal Research · 2016 · 979 citations
4Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockadeOriginal Research · 2016 · 1,339 citations
5Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infectionOriginal Research · 2023 · 25 citations

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