Risk Factors of Atherosclerotic Diseases - Executive Summary of Japan Atherosclerosis Society (JAS) Guideline for Diagnosis and Prevention of Atherosclerotic Cardiovascular Diseases for Japanese

The risk factors of coronary artery disease (CAD) used for the categorization and setting of management targets have been established on the basis of evidence accumulated over a long time (Table According to a 14-year follow-up in NIPPON DATA80 conducted in Japan, also, factors related to CAD were the TC level, age, systolic blood pressure, blood glucose level, and cigarette smoking (Reference 1-A, B) 1) . Similar results have been obtained by a 19-year follow-up, in which the hazard level was 2.11 (95% confidence interval: 0.92-4.84) at a TC level of 200-219 mg/dL, 2.17 (0.89-5.25) at 220-239 mg/dL, and 3.74 (1.44-9.76) at 240-259 mg/dL in males when the hazard level at a TC level of 160-179 mg/dL is defined as 1 2) . Also, while the TG level is an important factor clearly related to CAD, evidence that indicates their direct relationship is insufficient. Therefore, it was not used for categorization and was included as a management target alone. In addition, consideration of some risk factors that have been clarified recently (Table These risk factors are discussed below.