Why the study?
Developing cardioprotective therapies requires methods to simultaneously characterize the extent and localization of myocardial ischemia/reperfusion injury and ensuing inflammatory responses in whole hearts over time.
Population
Fluorescence-labeled whole hearts with experimental myocardial ischemia/reperfusion injury
Design
Preclinical imaging study using BALANCE clearing with light sheet fluorescence microscopy
Authors
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Enables high-resolution 3D mapping of myocardial I/R injury in preclinical models; leaves open clinical translation of BALANCE-based imaging.
A novel 3D imaging method combining BALANCE clearing and light sheet fluorescence microscopy allows detailed spatial and temporal characterization of myocardial ischemia/reperfusion injury and healing.
Merz et al. (2019) studied this question.
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