Does whole-body MRI detect skeletal muscle abnormalities in asymptomatic female dystrophinopathy carriers compared to controls?
Whole-body MRI can detect skeletal muscle involvement in asymptomatic female dystrophinopathy carriers, which may facilitate early detection and management of complications.
Background and Objectives: carriers who were asymptomatic at the time of the study and female control participants using whole-body MRI (WB-MRI) and correlate the findings with clinical and genetic data. Methods: carriers. Results: < 0.001), particularly in muscles of the calves, thighs, and pelvic region. The most frequently affected muscles were gastrocnemius, gluteus maximus, and soleus. No correlations were found between the MRI results and the clinical and genetic data. Discussion: female carriers will facilitate early detection and management of complications.
Vigliano et al. (Tue,) studied this question.