Renin and Survival in Patients Given Angiotensin II for Catecholamine-Resistant Vasodilatory Shock. A Clinical Trial

Figure 1.. Renin–angiotensin–aldosterone system disturbance hypothesis. The green arrows indicate an increase, the red arrows a decrease, and the red cross marks loss of function. ACE = angiotensin-converting enzyme.

Figure 2.. Serum angiotensin I and renin concentrations. (A) Serum angiotensin I concentrations. (B) Serum renin concentrations. All values are presented as the median (interquartile range).

Figure 3.. Kaplan-Meier survival plot according to renin concentrations and treatment with angiotensin II or placebo. (A) Day 28 survival: renin concentration below population median. (B) Day 28 survival: renin concentration above population median. CI = confidence interval; HR = hazard ratio.

Figure 4.. Cubic splines of mortality and baseline serum renin. Baseline renin is shown with log scale. LJPC501 = angiotensin II.