Effective immune-inflammation index for ulcerative colitis and activity assessments

BACKGROUND: The inverse association between systemic immune-inflammation index (SII) and overall survival in tumors has been studied. AIM: To evaluate the hematological indexes for assessing the activity of ulcerative colitis (UC). METHODS: In this case-control study, 172 UC patients and healthy participants were included. Comparisons were made among groups of white blood cells, hemoglobin, platelets, neutrophils, lymphocytes, monocytes, SII, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR). The relationship with hematological inflammation was verified by Spearman correlation analyses. The efficiency of SII, NLR, and PLR for distinguishing between UC and severe disease status was assessed by the receiver operator curve and logistic regression analyses. CONCLUSION: SII has a certain value in confirming UC and identifying its activity.