Regulation of Phospholipid Biosynthesis in the Yeast Saccharomyces cerevisiae

Phospholipids are key molecules that contribute to the structural definition of cells and that participate in the regulation of cellular processes. Phospholipid metabolism is a major activity that cells engage in throughout their growth. The yeast, Saccharomyces cerevisiae, serves as a model system in which to study the regulation of phospholipid synthesis and its regulation in eucaryotes. Its membranous organelles, the lipids that comprise these membranes, and the phospholipid biosynthetic pathways that generate these membranes typify eucaryotic cells (1, 2).