Key result
Medial arterial calcification lacks causal therapies, highlighting need for genetics and omics-based research.
Why the study?
Medial arterial calcification is a distinct chronic systemic vascular disorder with unknown pathogenesis and no causal therapy available, necessitating a comprehensive review of current knowledge and future research directions.
Medial arterial calcification is a distinct systemic vascular disorder with unknown pathogenesis and no causal therapy, highlighting the need for genetics and omics-based research.
Medial arterial calcification (MAC) is a chronic systemic vascular disorder distinct from atherosclerosis that is frequently but not always associated with diabetes mellitus, chronic kidney disease, and aging. MAC is also a part of more complex phenotypes in numerous less common diseases. The hallmarks of MAC include disseminated and progressive precipitation of calcium phosphate within the medial layer, a prolonged and clinically silent course, and compromise of hemodynamics associated with chronic limb-threatening ischemia. MAC increases the risk of complications during vascular interventions and mitigates their outcomes. With the exception of rare monogenetic defects affecting adenosine triphosphate metabolism, MAC pathogenesis remains unknown, and causal therapy is not available. Implementation of genetics and omics-based approaches in research recognizing the critical importance of calcium phosphate thermodynamics holds promise to unravel MAC molecular pathogenesis and to provide guidance for therapy. The current state of knowledge concerning MAC is reviewed, and future perspectives are outlined.
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Lanzer et al. (2021) conducted a review in Medial arterial calcification. Medial arterial calcification is a chronic systemic vascular disorder with unknown pathogenesis and no available causal therapy, though genetics and omics-based approaches hold promise for future research.
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