ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use

“The key messages we want to get through to physicians and patients is that physicians should not prescribe [PPIs] routinely, but they should weigh the individual risks and benefits for each patient. Our consensus group really tried to... highlight the group in which the proton pump inhibitors would have the most bang for the buck.”

Mark HlatkyProfessor of cardiovascular medicine, Stanford University

“In patients at high risk of GI bleeding who require antiplatelet therapy for heart disease, the balance of risk and benefit favor use of proton-pump inhibitors. In patients at low risk of GI bleeding, however, the balance of risk and benefit tips away from using proton-pump inhibitors together with antiplatelet drugs.”

Shaun G. GoodmanCardiologist, St. Michael's Hospital, Toronto

“a thoughtful and concise review of the existing data together with clear recommendations for this sometimes controversial, often confusing topic which has important implications for day-to-day practice”