Answers are grounded in this paper and cite their sources.
H NMR spectra detecting chemical features that are positively ("hot") or negatively ("cold") correlated with bioactivity prior to any isolation. ELINA is exemplified in the discovery of steroid sulfatase (STS) inhibiting lanostane triterpenes (LTTs) from a complex extract of the polypore fungus Fomitopsis pinicola.
No takes yet. Share an insight, caveat, or question.
Grienke et al. (2019) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: