Does serology after vaccination predict cross-protection against foot-and-mouth disease virus strains?
Establishing cut-off serological titres can score the adequacy of vaccine-induced immunity and facilitate the monitoring of FMD vaccination in the field.
reciprocal titres associated on average with 75% protection (with 95% credible limits) were: Group 1: 2.46 (2.11-2.97); Group 2: 1.67 (1.49-1.92); Group 3: 1.17 (1.06-1.30). Further cross-protection data are needed to understand the factors that underpin this variability and to develop more robust antibody thresholds. Establishing cut-off serological titres that can be used to score the adequacy of vaccine-induced immunity will facilitate the monitoring and thereby the performance of FMD vaccination in the field.
Gubbins et al. (Thu,) studied this question.