April 1, 1997Circulation

Acute T-Cell Activation Is Detectable in Unstable Angina

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Why the study?

Is acute T-cell activation detectable in patients with unstable angina compared to stable angina and healthy controls?

Population

95 subjects, including 29 patients with proven unstable angina, 36 with stable angina, and 30 healthy subjects

Design

Cohort

Follow-up

90 days

Authors

GSGian Gastone Neri SerneriUniversity of Siena DPDomenico PriscoVascular Medicine FMFrancesca MartiniUniversity of Pisa

Discussion

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Implication

Supports immune-inflammatory role in unstable angina; hypothesis-generating for targeted therapies pending prospective trials.

Structured PICO

Is acute T-cell activation detectable in patients with unstable angina compared to stable angina and healthy controls?

Population

95 subjects, including 29 patients with proven unstable angina, 36 with stable angina, and 30 healthy subjects

Comparator

Patients with stable angina and healthy subjects

Outcome

Lymphocyte activation (expression of IL-2R, CD25, CD71, HLA-DR) and plasma sIL-2R levelssurrogate

Acute T-cell activation is present in unstable angina and lasts 6 to 8 weeks, supporting an immune-mediated inflammatory component in its pathophysiology.

Cite This Study

Serneri et al. (1997) studied this question.

synapsesocial.com/papers/69ffccc67955d29dc3260fb3 https://doi.org/10.1161/01.cir.95.7.1806

View Full Paper

Ask AI

Bookmark

Acute T-Cell Activation Is Detectable in Unstable Angina

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Acute T-Cell Activation Is Detectable in Unstable Angina

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider