Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis

Barbara Chiavarina; Brunella Costanza; Roberto Ronca; Arnaud Blomme; Sara Rezzola; Paola Chiodelli; Ambre Giguelay; Guillame Belthier; Gilles Doumont; Gaëtan Van Simaeys; Simon Lacroix; Takehiko Yokobori; Bilguun Erkhem‐Ochir; Patrick Balaguer; Vincent Cavaillès; Eric Fabbrizio; Emmanuel Di Valentin; Stéphanie Gofflot; Olivier Detry; Guy Jérusalem; Serge Goldman; Philippe Delvenne; Akeila Bellahcène; Julie Pannequin; Vincent Castronovo; Andrei Turtoï

doi:10.7150/thno.51507

Abstract

TGFβ signaling in CRC cells directly contributes to their metastatic potential and stromal cell-independence. Proteins downstream of activated TGFβ, such as TGFBI, represent novel diagnostic and therapeutic targets for more specific anti-metastatic therapies.

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Chiavarina et al. (2020) studied this question.

synapsesocial.com/papers/69ffd324831589f3542daa29 https://doi.org/10.7150/thno.51507

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Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis

Abstract

Discussion

Cite This Study

Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis

Abstract

Discussion

Cite This Study

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