Population
Cholesterol-fed rabbits with balloon injury of the thoracic aorta (n=30)
Comparison
Intravenous injection of radiolabeled Lp(a) vs Intravenous injection of radiolabeled LDL
Design
Preclinical
Follow-up
up to 26 hours
Authors
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Lp(a) may preferentially accumulate at injury sites; leaves open mechanistic role and human relevance.
In a rabbit model, Lp(a) accumulates preferentially compared to LDL in injured arterial walls, suggesting a specific mechanism for its atherogenicity at sites of vascular injury.
Nielsen et al. (1996) studied this question.