H NMR, and AFM analysis. The formed SCPN are tunable in size (2-5 nm), depending on the molecular weight of the parent linear macromolecule. Furthermore, cytotoxicity studies revealed that the SCPN, which were covalently cross-linked by biodegradable polyester linkages, were nontoxic toward human embryonic kidney (HEK293T) cells. This study demonstrates the efficiency and versatility of this approach to generate uniformly sized soft nanoparticles with tunable dimensions that are potentially useful for a range of targeted applications, including drug delivery systems and membranes for gas separation technologies.
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Wong et al. (2014) studied this question.
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